Cug initiation and frameshifting enable production of dipeptide repeat proteins from als/ftd c9orf72 transcripts

HIGHLIGHTS

• who: Ricardos Tabet from the MassGeneral Institute Boston, MA, USAHarvard University have published the paper: CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 28/04/2017
• what: The authors provide mechanistic insights delineating the different steps needed to recruit the ribosome and initiate RAN translation from G4C2 expansions to produce poly-GA, GP, and GR proteins. The authors demonstrate here that G4C2 repeat-containing transcripts associate with ribosomal subunits independently of translational factors. | 9:152 The authors provide new insights . . .
  

   

  

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