Management of hyperkalemia in the acutely ill patient

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  • who: François Dépret from the Additional file Additional file, : Figure S Gastrointestinal absorption site of ZS-9, SPS and patiromer. The majority of potassium is in the distal gastrointestinal (GI) tract (e_g, the colon). Both sodium polystyrene sulfonate (SPS) and patiromer are concentration dependent binding (with patiromer being better than SPS). Since there is not relatively much potassium in the early part of the GI tract, SPS and patiromer have less of an effect because there is less for them to bind. Furthermore divalent cation ­(Ca2+ and M ­ g2+) are inadvertently pick up as well . . .

     

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