Inflammasome activation in nadph oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

HIGHLIGHTS

• who: Zurich Open Repository et al. from the University ofHôpital Necker-Enfants Malades, University Paris Descartes, Paris, France have published the research: Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease, in the Journal: (JOURNAL) of January/13,/2010
• what: The authors report that mononuclear phagocytes from CGD patients activated caspase-1 and produced biologically active interleukin-1beta (IL-1beta) in response to danger signals.

SUMMARY

Chronic granulomatous disease (CGD) is a genetically heterogeneous primary immunodeficiency caused by defects in phagocyte nicotinamide_adenine_dinucleotide phosphate (NADPH) oxidase . . .

 



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