Myosin sequestration regulates sarcomere function, cardiomyocyte energetics, and metabolism, informing the pathogenesis of hypertrophic cardiomyopathy

HIGHLIGHTS

• who: Circulation and collaborators from the Rodent Studies All animal experiments were performed in accordance with protocols that were reviewed and approved by institutional boards in accordance with the Animal Care and Use Committee of the University of Western Ontario and Harvard Medical SchoolVentricular heart tissues were snap frozen in have published the article: Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy, in the Journal: (JOURNAL) of March/10,/2020
• what: By integrating structural, biophysical, biochemical, and clinical information, the authors provide evidence that dynamic conformations of myosin . . .
  

   

  

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