A non-conserved amino acid variant regulates differential signalling between human and mouse cd28

HIGHLIGHTS

  • who: A non-conserved amino acid et al. from the Laboratory Sapienza University, Marseille, France, Life Sciences Global Assay and Applications Development, Beckman Coulter, Immunotech SAS, Marseille, France. have published the research: A non-conserved amino acid variant regulates differential signalling between human and mouse CD28, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS

SUMMARY

    By comparing the sequence of the cytoplasmic tail of CD28 between human and mouse, a single amino_acid variant within the C-terminal prolinerich motif was found: P212 in human CD28 (hCD28) (PYAPP212) vs. A210 (PYAPA210) in mouse. TNF mRNA . . .

     

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