Munc18 and munc13 serve as a functional template to orchestrate neuronal snare complex assembly

HIGHLIGHTS

• who: Shen Wang from the LaboratoryHuazhong University of Science and Technology, Wuhan, China have published the research work: Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• how: Aided by the crystal_structure of the SNARE complex6 (Fig 1a) the authors designed a series of mutations or truncations on the SNAREs (all mutations or truncations used throughout the study are summarized in Supplementary Table 1) and tested their potential defects in MUN-catalyzed transition from the Munc18-1/Syx1 complex to the SNARE complex . . .
  

   

  

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