Development of conformational antibodies to detect bcl-xl’s amyloid aggregates in metal-induced apoptotic neuroblastoma cells

HIGHLIGHTS

• who: Alexis Gonneaud and collaborators from the Laboratoire de Chimie et Biologie des Métaux, Université Grenoble Alpes, CNRS, CEA, médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC J E , Canada have published the article: Development of Conformational Antibodies to Detect Bcl-xL’s Amyloid Aggregates in Metal-Induced Apoptotic Neuroblastoma Cells, in the Journal: (JOURNAL)
• what: The authors show that cleaved Bcl-xL (∆N-Bcl-xL) forms fibers that exhibit the features of amyloid structures (BclxLcf37). In this study, in study, vitro, the authors show uponthat caspase like-cleavage . . .
  

   

  

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