HIGHLIGHTS
- who: Catherine Postic from the France, Université Diderot, Sorbonne, France, CHU, Lille, France United Arab Emirates University have published the research: O-GlcNacylation Links TxNIP to Inflammasome Activation in Pancreatic β Cells, in the Journal: (JOURNAL)
- what: The study demonstrates that the TxNIP protein is modified by O-GlcNAcylation in both rodent and human pancreatic β cells and that this modification enhances its interaction with its binding partner NLRP3, leading in turn to inflammasome activation. The authors provide several lines of evidence in glucose concentrations (33 mM glucose) further decreased the BRET signal. The authors report here . . .
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