HIGHLIGHTS
- who: Gisella Figlioli from the (UNIVERSITY) have published the article: The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer, in the Journal: (JOURNAL)
- what: The authors investigated the association of the three recurrent FANCM truncating variants p.Arg658*, p.Gln1701*, and p.Arg1931*, with breast cancer risk overall and by tumor subtype. The authors provide evidence that lack of FANCM protein and truncating variants identified in breast cancer patients are associated with increased sensitivity to the PARPi olaparib suggesting a therapeutic opportunity to treat FANCM-associated breast tumors that . . .
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