Posttranslational modifications and the immunogenicity of biotherapeutics

HIGHLIGHTS

  • who: Posttranslational, Modifications and Roy, Jefferis from the Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham , TT, UK have published the research: Posttranslational Modifications and the Immunogenicity of Biotherapeutics, in the Journal: (JOURNAL) of 26/01/2016

SUMMARY

    Overview of Co- and Posttranslational Modifications Variations in protein structure from that predicted by open_reading_frame gene sequences may be introduced during transcription and/or translation, by misincorporation at the DNA, RNA, and amino_acid level, and the introduction of CTMs. The structural profile, in_vivo, may vary with age, sex . . .

     

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