HIGHLIGHTS
- who: Huimei Chen from the Department University of Bari, Bari, Italy, SOC di Anatomia Patologica, Ospedale San Giovanni di Dio, Florence, Italy. have published the Article: WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors demonstrate a previously unappreciated role for WWP2 in the pathophysiological cardiovascular system, and elucidate how this gene regulates SMAD function and the downstream fibrogenic response in the diseased heart. Using longitudinal cardiac transcriptome data from a mouse genetic model of HF30, the authors show that this hECM network is enriched . . .
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