HIGHLIGHTS
SUMMARY
The authors demonstrate the potential of ALZ-201 to protect against the neurotoxicity of soluble AD brain extracts in cultured primary neurons, providing in_vitro proof-of-concept for the efficacy of targeting a low-abundant, toxic Aβ42 species to ameliorate neurodegeneration. This demonstrates that ALZ-201 is reactive towards rAβ42 oligomer(s) and also suggests that while actively aggregating in_vitro, only a minute fraction of the Aβ42 peptide is in this ALZ-201-reactive oligomeric state. Immunodepletion with ALZ‑201 reduces neurotoxicity of brain extracts from post‑mortem human AD tissue . . .
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