Aβ42 oligomers trigger synaptic loss through camkk2-ampk-dependent effectors coordinating mitochondrial fission and mitophagy

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• who: Annie Lee from the Animals Mice were used according to protocols approved by the Institutional Animal Care and Use Committee (IACUC) at Columbia University and in accordance with National Institutes of Health guidelinesTimepregnant , females were purchased from Charles Rivers., SvJ, C Bl/ J nontransgenic mice, and hemizygous transgenic mice from line, .Cg-Zbtb Tg(PDGFB-APPSwInd) Lms/ Mmjax (hereafter referred as, ) (The Jackson Laboratory stock #006293) were maintained in a, hour light/dark cycle. , mice express human APP carrying the Swedish and Indiana mutations under a PDGFu03b2 promoter8, . AMPKu03b1 F/Fu03b1 F/F double conditional knockout . . .
  

   

  

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