A c-terminally truncated tdp-43 splice isoform exhibits neuronal specific cytoplasmic aggregation and contributes to tdp-43 pathology in als

HIGHLIGHTS

• who: Janice Robertson from the University of Toronto, Toronto, ON, Canada have published the article: A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS, in the Journal: (JOURNAL)
• what: To test for cell-type variabilities in subcellular distributions, the authors demonstrate that both TDP43-FL and TDP43C-spl are localized to the nucleus in astrocytic and microglial cell lines. Using a novel antibody raised to the C-terminal unique sequence created by the splicing deletion in exon 6, the authors show upregulation of . . .
  

   

  

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