A cacna1c variant associated with cardiac arrhythmias provides mechanistic insights in the calmodulation of l-type ca2+ channels

HIGHLIGHTS

• who: Juan Zhao from the (UNIVERSITY) have published the research: A CACNA1C variant associated with cardiac arrhythmias provides mechanistic insights in the calmodulation of L-type Ca2+ channels, in the Journal: (JOURNAL) of June/12,/2022
• what: In the experiments shown in Figures 4 and 5, the constructs were pCMV-CaVu03b22a with pCMV-CaV1.2 WT or G449R and pcDNA3-HisB-cMyc-CaM WT and used CaM as the bait.
• how: The data are compatible with the proposition that the longer u03b1-helix enhances the coupling of the I-II linker with the . . .
  

   

  

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