A careful reassessment of anthracycline use in curable breast cancer

HIGHLIGHTS

• who: Sara Alsterlind Hurvitz from the were transfected with , cDNA to be rendered , overexpressing and then treated with tamoxifen or chemotherapyThese cells proved resistant to tamoxifen both in vitro and in vivo, however, their sensitivity to anthracycline chemotherapy was unchanged despite , overexpression105. Similarly, Pegram and colleagues transfected full-length human HER2/neu cDNA into MCF7, MDA-MB-231, MDA-MB-435, and , breast cancer cell lines and two ovarian cancer cell lines and compared the response of these cell lines in vitro and in vivo to that of mock-transfected parental lines106. These experiments also failed to . . .
  

   

  

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