A cassette of basic amino acids in histone h2b regulates nucleosome dynamics and access to dna damage

HIGHLIGHTS

• who: Yesenia Rodriguez from the (UNIVERSITY) have published the research: A cassette of basic amino acids in histone H2B regulates nucleosome dynamics and access to DNA damage, in the Journal: (JOURNAL) of October/10,/2017
• what: The authors characterized the stability and dynamics of ⌬HBR mutant nucleosome core particles (NCPs) in_vitro by restriction enzyme accessibility (REA), FRET, and temperature-induced sliding of histone octamers. The authors show that the activity of base excision repair enzymes at uracil lesions and single nucleotide gaps is enhanced in a site-specific manner in ⌬HBR-NCPs. The authors wished . . .
  

   

  

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