HIGHLIGHTS
- who: Press and collaborators from the Institut University of United Kingdom have published the research work: A central role for canonical PRC1 in shaping the 3D nuclear landscape, in the Journal: (JOURNAL)
- what: The authors examine the role of Polycomb-repressive complex 1 (PRC1) in shaping 3D genome organization in mouse embryonic stem cells (mESCs). Using a combination of imaging and Hi-C analyses the authors show that PRC1-mediated long-range interactions are independent of CTCF and can bridge sites at a megabase scale. The authors demonstrate that PcG targets coalesce in vivo and . . .
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