A chemical-genomic screen of neglected antibiotics reveals illicit transport of kasugamycin and blasticidin s

HIGHLIGHTS

  • who: Anthony L. Shiver and collaborators from the Graduate Group in Biophysics, University California, San Francisco, San Francisco, California, United have published the paper: A Chemical-Genomic Screen of Neglected Antibiotics Reveals Illicit Transport of Kasugamycin and Blasticidin S, in the Journal: (JOURNAL) of June/29,/2016
  • what: The authors show that the screen identifies new resistance determinants for these antibiotics including a common signature from two antimicrobials and used to treat crop diseases like rice blast and fire blight. The authors provide evidence that these compounds hijack an overlapping set peptide ABC-importers to . . .

     

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