A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication

HIGHLIGHTS

• who: Marialuisa Perrotta from the (UNIVERSITY) have published the article: A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 27/09/2016
• what: The authors show that hypertensive challenges activate splenic nerve discharge to prime immune response. The authors show that selectively thermoablating the splenic nerve prevents T cell egression and protects against hypertension. The experiments showed that a7nAChR KO mice are protected from AngII-induced hypertension.
• how: Similar results were obtained with both radiotelemetry (Supplementary Fig 7bc) and tail . . .
  

   

  

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