A chromosomal mutation is superior to a plasmid-encoded mutation for plasmid fitness cost compensation

HIGHLIGHTS

• What: The authors develop theory and a that arose during evolution experiments between Pseudomonas fluorescens SBW25 and its dominated in the experiments including conditions with numerous recipients due to a more efficacious mechanism of compensation and advantages arising from transmission of dominate even in competition against an uncompensated plasmid. The authors show that, contrary to expectations, plaCM performs poorly in competition with chrCM under all tested conditions due to lower efficacy of amelioration, a probable trade-off against horizontal transmission or establishment in transconjugants, and an overlooked benefit of chrCM that effectively enables these cells to "weaponise . . .
  

   

  

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