A comprehensive strategy combining feature selection and local optimization algorithm to optimize the design of low-density chip for genomic selection

HIGHLIGHTS

SUMMARY

An appealingly suitable solution is to apply lower-density SNP chips, and then impute them to medium- or high-density genotypes for practical GS application. Commercial low-density SNP chips, such as Illumina Bovine3K BeadChip and BovineLD BeadChip (6K), were designed to support imputation to higher-density genotypes in dairy 2 of 11 and beef cattle and were verified to perform well in terms of both imputation accuracies and genomic prediction accuracies. Developing a low-density SNP panel and then imputing to higher density panels is a cost-effective solution for practical application of . . .

 



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