A conserved acidic residue in the c-terminal flexible loop of hiv-1 nef contributes to the activity of serinc5and cd4 downregulation

HIGHLIGHTS

• who: Claudia Firrito and collaborators from the Department of Cellular, Computational and integrative Biology, University of Trento, Trento, Italy have published the research work: A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5and CD4 Downregulation, in the Journal: Viruses 2023, 652 of 28/Nov/2022
• how: The effect of the three single substitutions (V134E Y136F and D150N) on the activity against SERINC5 was tested in a single-cycle infectivity assay. The mutants similarly expressed in the lysate of virus-producing cells were tested for . . .
  

   

  

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