A context-dependent and disordered ubiquitin-binding motif

HIGHLIGHTS

• who: Jesper E. Dreier from the Structural Biology and NMR Laboratory, University of Copenhagen, Ole Maaloes Vej, Copenhagen N, Denmark have published the article: A context-dependent and disordered ubiquitin-binding motif, in the Journal: (JOURNAL)
• what: The authors show that the affinity of the motif is low and moldable by the surrounding disordered chain allowing for an enhanced interaction surface with whereby the affinity increases ~ tenfold. As the ubiquitin used in this study had the TEV-cleavage linker, an N-terminal free cysteine as well as the 6xhis tag, 15N-NOESY-HSQC (mixing time . . .
  

   

  

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