HIGHLIGHTS
SUMMARY
IL-22 signals through a heterodimeric receptor consisting of the ubiquitously expressed IL-10 receptor 2 (IL-10R2) and the IL-22-specific receptor IL-22 receptor 1 (IL-22R1), which is predominately expressed on non-hematopoietic cells. A delicate balance between IL-22 and IL-22BP is generally needed physiologically, since both the lack of IL-22 as well as its uncontrolled expression can lead to pathogenesis such as infections or cancer development, respectively. IL-22 was mainly produced by CD4+ T_cells during liver carcinogenesis, while IL-22BP was abundantly secreted by neutrophils . . .
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