A cytosolic chaperone complex controls folding and degradation of type iii cd38

HIGHLIGHTS

• who: Yang Wu from the (UNIVERSITY) have published the research: A cytosolic chaperone complex controls folding and degradation of type III CD38, in the Journal: (JOURNAL) of September/12,/2018
• what: Mechanistically, the authors show that Hsc70 mediates lysosomal degradation of type III CD38, requiring the lysosomal receptor Lamp2A and the C19-motif in the C terminus of CD38.
• how: Chaperones regulate the folding and proteostasis of sCD38 To investigate the roles of these chaperones in sCD38 proteostasis the authors conducted loss-of-function experiments with both siRNA-knockdown and specific inhibitors. Showed . . .
  

   

  

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