HIGHLIGHTS
SUMMARY
Use of agents impairing medullary oxygenation, such as nonsteroidal antiinflammatory drugs (NSAIDs) and radiocontrast agents (Szalat et_al, 2018). Some propensity score analysis comparing SGLT2i with other antidiabetics (dipeptidyl peptidase 4 inhibitors) reported that AKI risk was reduced in SGLT2i users, but the mechanism is unknown yet (Nadkarni et_al, 2017; Sridhar et_al, 2020). It was also suggested that SGLT2i can cause hyperuricosuria (Chino et_al, 2014; Novikov et_al, 2019), which may confer a greater risk for specific types of kidney stones. SGLT2i may induce excessive diuresis which can lead to intravascular volume depletion, particularly in hemodynamically . . .
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