HIGHLIGHTS
SUMMARY
In support to this idea, the authors recently demonstrated that breakage of GB integrity leads to activation of islet-reactive T_cells and triggers autoimmune Type 1 Diabetes (T1D). Keyword anti-inflammatory diet (AID), Type 1 diabetes, gut barrier integrity, mucus layer, gut microbiota, regulatory T_cells GRAPHICAL Abstract As consequence, gut immune homeostasis is restored with an expansion of regulatory T_cell subsets (FoxP3+ Treg and IL-10+Tr1 cells) in the intestinal mucosa but also in pancreatic lymph nodes and islets where they may limit aggressiveness of islet-reactive T_cells thus inducing protection from autoimmune . . .
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