A direct nuclear magnetic resonance method to investigate lysine acetylation of intrinsically disordered proteins

HIGHLIGHTS

• who: Methods et al. from the Upstate Medical University, United States have published the research: A direct nuclear magnetic resonance method to investigate lysine acetylation of intrinsically disordered proteins, in the Journal: (JOURNAL)
• what: The authors demonstrate enzymatic transfer of uniformly 13C-acetyl groups, either with or without concomitant isotopic enrichment of the substrate protein. The authors report here modifications to the 13C direct-detect CACO and CON experiments that yield optimized detection of the acetamide functional_group created upon lysine Nu03b5 acetylation. As a test case, here the authors provide data acquired from acetylation of . . .
  

   

  

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