A disintegrin and metalloenzyme (adam) 17 activation is regulated by a 5 b 1 integrin in kidney mesangial cells

HIGHLIGHTS

  • who: Pal Gooz and collaborators from the Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America, Department of Biochemistry and Molecular have published the article: A Disintegrin and Metalloenzyme (ADAM) 17 Activation Is Regulated by a 5 b 1 Integrin in Kidney Mesangial Cells, in the Journal: (JOURNAL) of December/22,/2011
  • what: The authors wanted to characterize the role of a5b1 integrin in ADAM17 activity regulation during G protein-coupled receptor (GPCR) stimulation. The authors demonstrate - for the first time that a5b1 integrin-binding regulates ADAM17 enzymatic activity . . .

     

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