A disintegrin and metalloproteinase-10 (adam-10) mediates dn30 antibody-induced shedding of the met surface receptor*

HIGHLIGHTS

  • who: Florian Schelter from the (UNIVERSITY) have published the research: A Disintegrin and Metalloproteinase-10 (ADAM-10) Mediates DN30 Antibody-induced Shedding of the Met Surface Receptor*, in the Journal: (JOURNAL) of August/20,/2010
  • what: The authors show by a functional genetic approach that DN30 antibody-induced Met shedding is selectively mediated by ADAM-10. DN30-induced ADAM-10-mediated Shedding Reduced Met Activation-Next, the authors aimed to elucidate whether ADAM-10 was necessary for the suppression of Met signaling by DN30. This study shows the involvement of a specific endogenous protease in . . .

     

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