HIGHLIGHTS
SUMMARY
Myelination is essential for ensuring fast and efficient propagation of action potentials along axons and providing metabolic trophic support for axons. Next, the authors crossed NG2-Cre mice (Cre is specifically expressed in OPCs) with ADAM10 loxp/loxp mice with conditional knockout of ADAM10 in OPCs and investigated the role and mechanism of ADAM10 on OPCs development and myelination in the CNS. ADAM10 loxp/loxp mice (from Prof. Duan) were crossed with heterozygous NG2-Cre mice (Jackson Lab) to generate ADAM10 loxp/-and NG2-Cre+/- mice were bred with ADAM10 loxp/loxp mice to . . .
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