HIGHLIGHTS
- who: Yongheng Chen from the (UNIVERSITY) have published the research work: A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer, in the Journal: (JOURNAL) of 21/05/2022
- what: The authors report a novel disease-specific SE in IBD and CRC that drives oncogenic ETS2 expression through long-range regulation and further elucidated how disease-associated genetic variation modulates the transcription regulation via the ETS2-SE. In concert with these findings, the study showed that ETS2 was upregulated in IBD and higher ETS2 expression predicted resistance to . . .
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