A fe -dependent self-inhibited state in fl uences the druggability of human collagen lysyl hydroxylase (lh/plod) enzymes

HIGHLIGHTS

• who: . and collaborators from the University of Insubria, Italy have published the paper: A Fe -dependent self-inhibited state in fl uences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes, in the Journal: (JOURNAL)
• what: The results of this analysis show that most of the native contacts are maintained during the simulation time in both systems (Supplementary Figure S1A,B), while in LH3Fe1 some residues of the loop tend to weaken some of these interactions compared to LH3Fe2. This analysis showed that in most of the conformations visited during the dynamics, Arg599 forms . . .
  

   

  

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