HIGHLIGHTS
SUMMARY
The authors investigated some indicators of local T3 availability (T3 target genes and genes involved in TH signalling) and markers of astrocytes and microglia activation in the hippocampus of C57BL/6J and WSB/EiJ male mice treated with PTU. Euthyroid WSB/EiJ mice depicted a lower circulating total T4 than C57BL/6J mice (p=0.0003), but still in the euthyroid reference range for mice (see discussion section for details). In response to PTU treatment, circulating levels of total T4 decreased by 90% and 82% in C57BL/6J and WSB/EiJ mice, respectively, compared . . .
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