A flap motif in human serine hydroxymethyltransferase is important for structural stabilization, ligand binding, and control of product release

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  • who: Sakunrat Ubonprasert from the (UNIVERSITY) have published the article: A flap motif in human serine hydroxymethyltransferase is important for structural stabilization, ligand binding, and control of product release, in the Journal: (JOURNAL) of April/20,/2019
  • how: The results indicated that removal of the flap motif does not influence PLP absorption. The result indicated that hcSHMT/⌬flap coexists in tetrameric and dimeric forms which clearly differ from the WT showing almost a single peak at 12 ml of 206 kDa for tetramer and a very small fraction of 96-kDa dimer (Fig 2B). The . . .

     

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