A fundamental catalytic difference between zinc and manganese dependent enzymes revealed in a bacterial isatin hydrolase

HIGHLIGHTS

  • who: Theis Sommer from the Norwegian Center for Molecular Medicine, Nordic EMBL Partnership University of Oslo, Gaustadallu00e9en, have published the research: A fundamental catalytic difference between zinc and manganese dependent enzymes revealed in a bacterial isatin hydrolase, in the Journal: (JOURNAL) of 14/06/2018
  • what: Based on the identification of mechanistically important residues presented this work including the Mn2+ binding residues the active site the authors further present evidence that the Mn2+ dependent allantoate amidohydrolase (AAH) (E.C. displays striking similarity the active site geometry despite the differences the overall protein fold. this likely . . .

     

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