HIGHLIGHTS
- who: Igor V. Peshenko from the (UNIVERSITY) have published the article: A G86R mutation in the calcium-sensor protein GCAP1 alters regulation of retinal guanylyl cyclase and causes dominant cone-rod degeneration, in the Journal: (JOURNAL)
- what: The authors report a novel mutation, G86R, in the GCAP1 (GUCA1A) gene in a family with a dominant retinopathy.
- how: Best fit of the data were obtained with a sequential binding model resulting in two apparent KD values for the WT and the G86R mutant (Fig 7 A and B and Table 1).
SUMMARY . . .
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