A genome-wide crispr screen identifies calcoco2 as a regulator of beta cell function influencing type 2 diabetes risk

HIGHLIGHTS

• who: Antje K. Rottner from the (UNIVERSITY) have published the paper: A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk, in the Journal: (JOURNAL) of 21/05/2021
• what: The authors focused the follow -up studies on one of the 20 predicted effector genes and the screening hit CALCOCO2 as its role in human beta cells has not been explored (Fig 4a)14,46-49. Collectively, the authors demonstrate that T2D-associated risk variants associated with CALCOCO2 affect insulin secretion in primary human islets although . . .
  

   

  

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