A genome-wide crispr screen identifies factors regulating pluripotency exit in mouse embryonic stem cells

HIGHLIGHTS

• who: Chen Gao et al. from the State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University have published the Article: A Genome-Wide CRISPR Screen Identifies Factors Regulating Pluripotency Exit in Mouse Embryonic Stem Cells, in the Journal: Cells 2022, 11, 2289. of 23/07/2022
• what: The authors isolated NANOG-GFP mESCs from the NANOG-GFP knock-in mouse and used NANOG-GFP expression as a convenient pluripotency reporter to facilitate the screening . Fittingly, these biological processes are critical for the regulation of pluripotency exit , supporting the objectives of the screen . . .
  

   

  

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