HIGHLIGHTS
SUMMARY
Although trans contacts are non-random and there is evidence of trans-regulatory interactions, studying the functional role of these interactions is difficult due to the high sparsity of available chromatin contact maps in trans. Obtaining high-density chromatin contact maps at all genomic distances and in trans is not yet feasible with most existing maps being essentially probabilistic in nature, capturing some fraction of likely present contacts in a distance-dependent manner. From Hi-C experiments, an nxn chromatin contact matrix is generated where the genome is divided into n equally sized bins . . .
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