A gold standard-derived modular barcoding approach to cancer transcriptomics

HIGHLIGHTS

  • What: In this resource the authors develop an approach that creates and assembles cancer type-specific gene expression modules into flexible barcodes allowing for adaptation to wide variety of uses. Specifically the authors propose that modules organically from high-quality standards such as The authors show that such modules can: uncover novel gene relationships and nominate new functional memberships improve and speed up analysis of smaller or lower-resolution datasets re-create and expand known cancer subtyping schemes act as "decoder" to bridge seemingly disparate established gene signatures and_(5) efficiently apply single-cell RNA sequencing information . . .

     

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