HIGHLIGHTS
- who: Alex H. Wagner from the (UNIVERSITY) have published the article: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer, in the Journal: (JOURNAL)
- what: To test the effect of the harmonization methods on generating consensus, the authors evaluated the overlap of unique interpretation elements from each knowledgebase of the core dataset in comparison to unharmonized (but aggregated) data (Methods). Specifically, the authors evaluated the unique nature of the vast majority of genomic variants reported across these knowledgebases and demonstrated the challenge of developing a consensus interpretation given these disparities.
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