A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

HIGHLIGHTS

• who: PLoS BIOLOGY and colleagues from the University of Sciences, Moscow, Russia have published the Article: A Helical Structural Nucleus Is the Primary Elongating Unit of Insulin Amyloid Fibrils, in the Journal: (JOURNAL)
• what: The authors propose that the latter intermediate is an interesting target for small_molecules to prevent or reduce amyloid fibril formation. The authors report a state-of-the-art SAXS analysis of fibrillating insulin and determine the ab initio low-resolution structure of the amyloid fibril repeating unit. This study shows the power of SAXS analysis on data from amyloid systems, since . . .
  

   

  

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