A herpesvirus transactivator and cellular pou proteins extensively regulate dna binding of the host notch signaling protein rbp-jκ to the virus genome

HIGHLIGHTS

• who: Olga Gonzalez-Lopez from the (UNIVERSITY) have published the research work: A herpesvirus transactivator and cellular POU proteins extensively regulate DNA binding of the host Notch signaling protein RBP-Jκ to the virus genome, in the Journal: (JOURNAL) of December/26,/2018
• what: Although the authors used a ChIP/Southern blotting approach to confirm broad enhancement of RBP-J␬ binding to the viral genome during KSHV reactivation, the model had shortcomings . The authors identified and characterized KSHV DNA sequences critical for assembling productive Rta/RBP-J␬ complexes in KSHV-infected PEL (B) cells. The . . .
  

   

  

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