A hierarchy of selection pressures determines the organization of the t cell receptor repertoire

HIGHLIGHTS

SUMMARY

The ability to sustain effective T_cell immunity relies on a diverse ab heterodimeric T_cell receptor (TCR) repertoire generated by the stochastic variable, diversity and joining (VDJ) recombination mechanism. The encounter with cognate peptide-MHC complex (pMHC) also drives the differentiation of the T_cell. The strength of TCR stimulation can skew differentiation of memory versus effector T_cells and CD4+ regulatory (Treg) versus effector/memory CD4+ cells, linking TCR specificity to phenotype and function. In young individuals, the majority of the T_cell compartment is made up of naive cells, and the repertoire is shaped largely by . . .

 



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