A hif-independent, cd133-mediated mechanism of cisplatin resistance in glioblastoma cells

HIGHLIGHTS

  • who: Eroje M. Ahmed from the Division of Cancer and Stem Cells, Cancer Biology, University of Nottingham, Nottingham, UK have published the Article: A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells, in the Journal: (JOURNAL)
  • how: Similar results were obtained with U251 (Fig 3b) and U87 cells (Supplemental Fig 3D) cultured in 3D.

SUMMARY

    Hypoxic regions have also been shown to harbour GBM stem_cell populations. HIF-1α has been found to promote the survival of glioma cancer stem_cells under hypoxic conditions, and HIF-2α is thought to . . .

     

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