HIGHLIGHTS
- who: Elaine Thai et al. from the Rockefeller University Press JExp. Med. , Vol. , No. , e, have published the research work: A high-affinity antibody against the CSP N-terminal domain lacks inhibitory activity, in the Journal: (JOURNAL) of 03/09/2022
- what: To guide immunogen design, the authors seek a comprehensive understanding of the protective humoral response against Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP). By providing a detailed molecular and functional understanding of mAb 5D5 recognition of its epitope, the authors report that this anti-N-CSP antibody inefficiently binds to live Pf sporozoites and . . .
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