HIGHLIGHTS
SUMMARY
Besides promoting neuronal survival and contributing to synapse formation, synaptosome engulfment, and neurotransmitter transmission, astrocytes participate in brain homeostasis through BBB formation and function and end-feet that contact blood vessels (Cecchelli et_al, 2007; Vasile et_al, 2017). Co-culturing brain endothelial cells with the other types of NVU cells has been shown to improve BBB integrity in several studies (Gaillard et_al, 2001; Boveri et_al, 2005; Cucullo et_al, 2008; Malina et_al, 2009; Hatherell et_al, 2011; Lippmann et_al, 2014; Appelt-Menzel et_al, 2017). Several neuropathological conditions, including stroke, epilepsy, Parkinson`s and Alzheimer`s disease, are . . .
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