A kinome-targeted rnai-based screen links fgf signaling to h2ax phosphorylation in response to radiation

HIGHLIGHTS

• who: Sami Benzina from the CEA, IRTSV, Biologie à Grande Echelle, rue des Martyrs, Grenoble , France have published the research: A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation, in the Journal: (JOURNAL)
• what: The authors report small interfering RNA (siRNA) to characterize human kinases involved in H2AX phosphorylation. The authors demonstrate that in response to irradiation the cascade promotes activation and direct H2AX phosphorylation leading in turn to more efficient DNA repair. Because of the nucleus-to-nucleus variability of cH2AX-specific fluorescence, the authors compare histograms . . .
  

   

  

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